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Assay Detail

CHEMBL616592

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of the radioligand [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists.
Stjernlöf P, Elebring T, Nilsson J, Andersson B, Lagerkvist S, Svensson K, Ekman A, Carlsson A, Wikström H.
J Med Chem (1994) 37 : 3263 -3273
PubMed 7932553 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.35 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL304426 1 8.89
CHEMBL71625 1 8.85
CHEMBL71920 U-92,016-A 1 8.77
CHEMBL70589 1 8.74
CHEMBL307786 1 8.70
CHEMBL308347 1 8.57
CHEMBL71804 1 8.54
CHEMBL302172 1 8.15
CHEMBL56 8-OH-DPAT 1 8.06
CHEMBL65196 1 7.92
CHEMBL303021 1 7.90
CHEMBL302171 1 7.85
CHEMBL71899 1 6.74
CHEMBL308143 1 6.66
CHEMBL109268 1 6.39
CHEMBL68523 1 6.26
CHEMBL305341 1 6.24
CHEMBL285755 1 5.55
CHEMBL113378 1 5.33
CHEMBL325837 1 5.17
CHEMBL110032 1 5.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL304426 Ki = 1.3 nM 8.89
CHEMBL71625 Ki = 1.4 nM 8.85
CHEMBL71920 U-92,016-A Ki = 1.7 nM 8.77
CHEMBL70589 Ki = 1.8 nM 8.74
CHEMBL307786 Ki = 2.0 nM 8.70
CHEMBL308347 Ki = 2.7 nM 8.57
CHEMBL71804 Ki = 2.9 nM 8.54
CHEMBL302172 Ki = 7.0 nM 8.15
CHEMBL56 8-OH-DPAT Ki = 8.7 nM 8.06
CHEMBL65196 Ki = 12.0 nM 7.92
CHEMBL303021 Ki = 12.6 nM 7.90
CHEMBL302171 Ki = 14.0 nM 7.85
CHEMBL71899 Ki = 182.0 nM 6.74
CHEMBL308143 Ki = 220.0 nM 6.66
CHEMBL109268 Ki = 410.0 nM 6.39
CHEMBL68523 Ki = 550.0 nM 6.26
CHEMBL305341 Ki = 570.0 nM 6.24
CHEMBL285755 Ki = 2810.0 nM 5.55
CHEMBL113378 Ki = 4720.0 nM 5.33
CHEMBL325837 Ki = 6720.0 nM 5.17
CHEMBL110032 Ki = 8800.0 nM 5.06