Assay Detail
Binding
CHEMBL616595
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Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in rat cerebral cortex membrane
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment on 5-HT1A affinity/selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.02 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46918 | — | — | 1 | 8.62 |
| CHEMBL42706 | — | — | 1 | 8.42 |
| CHEMBL43992 | — | — | 1 | 8.39 |
| CHEMBL289873 | — | — | 1 | 8.36 |
| CHEMBL88715 | — | — | 1 | 8.29 |
| CHEMBL42810 | — | — | 1 | 8.26 |
| CHEMBL45253 | — | — | 1 | 8.24 |
| CHEMBL42644 | — | — | 1 | 8.14 |
| CHEMBL46881 | — | — | 1 | 8.06 |
| CHEMBL417709 | — | — | 1 | 8.00 |
| CHEMBL290039 | — | — | 1 | 7.95 |
| CHEMBL90165 | — | — | 1 | 7.91 |
| CHEMBL88594 | — | — | 1 | 7.91 |
| CHEMBL89380 | — | — | 1 | 7.86 |
| CHEMBL90384 | — | — | 1 | 7.82 |
| CHEMBL315472 | — | — | 1 | 7.76 |
| CHEMBL314997 | — | — | 1 | 7.61 |
| CHEMBL89677 | — | — | 1 | 7.61 |
| CHEMBL424432 | — | — | 1 | 7.55 |
| CHEMBL89950 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46918 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL42706 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL43992 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL289873 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL88715 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL42810 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL45253 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL42644 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL46881 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL417709 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL290039 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL90165 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL88594 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL89380 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL90384 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL315472 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL314997 | — | Ki | = | 24.3 | nM | 7.61 |
| CHEMBL89677 | — | Ki | = | 24.3 | nM | 7.61 |
| CHEMBL424432 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL89950 | — | Ki | = | 29.1 | nM | 7.54 |