Assay Detail
Functional
CHEMBL616647
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Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.47 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308042 | — | — | 1 | 6.86 |
| CHEMBL72178 | — | — | 1 | 6.82 |
| CHEMBL312448 | XYLOMETAZOLINE | 3.0 | 1 | 6.43 |
| CHEMBL70409 | — | — | 1 | 5.78 |
| CHEMBL308727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308042 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL72178 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL312448 | XYLOMETAZOLINE | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL70409 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL308727 | — | EC50 | > | 10000.0 | nM | - |