Assay Detail
Functional
CHEMBL616663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.84 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357034 | — | — | 1 | 9.66 |
| CHEMBL1278 | NARATRIPTAN | 4.0 | 1 | 8.80 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 8.52 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357034 | — | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL1278 | NARATRIPTAN | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL905 | RIZATRIPTAN | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 4.3 | nM | 8.37 |