Assay Detail
Binding
CHEMBL616666
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Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 8.30 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146285 | — | — | 1 | 9.30 |
| CHEMBL434125 | — | — | 1 | 9.10 |
| CHEMBL313714 | — | — | 1 | 9.10 |
| CHEMBL145815 | — | — | 1 | 9.05 |
| CHEMBL333341 | — | — | 1 | 9.05 |
| CHEMBL143947 | — | — | 1 | 9.00 |
| CHEMBL356808 | — | — | 1 | 8.89 |
| CHEMBL304857 | — | — | 1 | 8.82 |
| CHEMBL118012 | — | — | 1 | 8.77 |
| CHEMBL148233 | — | — | 1 | 8.74 |
| CHEMBL146991 | — | — | 1 | 8.66 |
| CHEMBL146132 | — | — | 1 | 8.59 |
| CHEMBL147660 | — | — | 1 | 8.55 |
| CHEMBL146483 | — | — | 1 | 8.52 |
| CHEMBL148194 | — | — | 1 | 8.47 |
| CHEMBL423212 | — | — | 1 | 8.46 |
| CHEMBL146131 | — | — | 1 | 8.44 |
| CHEMBL146024 | — | — | 1 | 8.38 |
| CHEMBL147838 | — | — | 1 | 8.33 |
| CHEMBL146335 | — | — | 1 | 8.30 |
| CHEMBL146628 | — | — | 1 | 8.29 |
| CHEMBL143893 | — | — | 1 | 8.25 |
| CHEMBL146129 | — | — | 1 | 8.22 |
| CHEMBL147907 | — | — | 1 | 8.21 |
| CHEMBL146502 | — | — | 1 | 8.17 |
| CHEMBL357408 | — | — | 1 | 8.15 |
| CHEMBL147961 | — | — | 1 | 8.13 |
| CHEMBL117046 | — | — | 1 | 8.12 |
| CHEMBL148085 | — | — | 1 | 8.05 |
| CHEMBL344537 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146285 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL434125 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL313714 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL145815 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL333341 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL143947 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL356808 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL304857 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL118012 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL148233 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL146991 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL146132 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL147660 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL146483 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL148194 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL423212 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL146131 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL146024 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL147838 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL146335 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL146628 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL143893 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL146129 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL147907 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL146502 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL357408 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL147961 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL117046 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL148085 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL344537 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL342805 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL423749 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL143952 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL148087 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL146729 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2112862 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL331970 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147853 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL148110 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL423022 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL144002 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL148095 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL356315 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL341854 | — | EC50 | = | 32.0 | nM | 7.50 |