Assay Detail
Functional
CHEMBL616668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 8.51 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164046 | — | — | 1 | 9.52 |
| CHEMBL296161 | — | — | 1 | 9.40 |
| CHEMBL160070 | — | — | 1 | 9.30 |
| CHEMBL159759 | — | — | 1 | 9.20 |
| CHEMBL420965 | — | — | 1 | 9.10 |
| CHEMBL349185 | — | — | 1 | 8.89 |
| CHEMBL117579 | — | — | 1 | 8.82 |
| CHEMBL159483 | — | — | 1 | 8.77 |
| CHEMBL351303 | — | — | 1 | 8.74 |
| CHEMBL161410 | — | — | 1 | 8.68 |
| CHEMBL326371 | — | — | 1 | 8.68 |
| CHEMBL116092 | — | — | 1 | 8.64 |
| CHEMBL349041 | — | — | 1 | 8.55 |
| CHEMBL424154 | — | — | 1 | 8.52 |
| CHEMBL159683 | — | — | 1 | 8.52 |
| CHEMBL350153 | — | — | 1 | 8.49 |
| CHEMBL161780 | — | — | 1 | 8.46 |
| CHEMBL159819 | — | — | 1 | 8.39 |
| CHEMBL348864 | — | — | 1 | 8.35 |
| CHEMBL161192 | — | — | 1 | 8.31 |
| CHEMBL348815 | — | — | 1 | 8.21 |
| CHEMBL349528 | — | — | 1 | 8.11 |
| CHEMBL441296 | — | — | 1 | 8.06 |
| CHEMBL161066 | — | — | 1 | 8.02 |
| CHEMBL349390 | — | — | 1 | 8.00 |
| CHEMBL159733 | — | — | 1 | 7.96 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.85 |
| CHEMBL420874 | — | — | 1 | 7.82 |
| CHEMBL435060 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164046 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL296161 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL160070 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL159759 | — | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL420965 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL349185 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL117579 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL159483 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL351303 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL161410 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL326371 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL116092 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL349041 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL424154 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL159683 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL350153 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL161780 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL159819 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL348864 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL161192 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL348815 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL349528 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL441296 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL161066 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL349390 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL159733 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL420874 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL435060 | — | EC50 | = | 31.0 | nM | 7.51 |