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Assay Detail

CHEMBL616678

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The binding of [125I]MPPI ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenates
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Hippocampus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.
Zhuang ZP, Kung MP, Kung HF.
J Med Chem (1994) 37 : 1406 -1407
PubMed 8182697 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 9.52 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29027 1 9.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29027 Kd = 0.3 nM 9.52