Assay Detail
Binding
CHEMBL616679
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Ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.51 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | — | 1 | 9.26 |
| CHEMBL342355 | — | — | 1 | 8.40 |
| CHEMBL147854 | — | — | 1 | 8.10 |
| CHEMBL91806 | — | — | 1 | 7.82 |
| CHEMBL148381 | — | — | 1 | 7.47 |
| CHEMBL147972 | — | — | 1 | 7.33 |
| CHEMBL146989 | — | — | 1 | 7.30 |
| CHEMBL147481 | — | — | 1 | 7.14 |
| CHEMBL273241 | — | — | 1 | 6.45 |
| CHEMBL439805 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL342355 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL147854 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL91806 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL148381 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL147972 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL146989 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL147481 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL273241 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL439805 | — | Ki | = | 1600.0 | nM | 5.80 |