Assay Detail
Binding
CHEMBL616680
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Ability to bind to central serotonin 5-hydroxytryptamine 1A receptor in vitro in hippocampus of the rat brain using [3H]8-OH-DPAT radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.70 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112360 | — | — | 1 | 8.96 |
| CHEMBL86719 | — | — | 1 | 8.68 |
| CHEMBL91588 | — | — | 1 | 7.98 |
| CHEMBL195047 | — | — | 1 | 7.96 |
| CHEMBL2112363 | — | — | 1 | 7.94 |
| CHEMBL328292 | — | — | 1 | 7.76 |
| CHEMBL193595 | — | — | 1 | 7.72 |
| CHEMBL2112351 | — | — | 1 | 7.64 |
| CHEMBL91021 | — | — | 1 | 7.60 |
| CHEMBL425567 | — | — | 1 | 7.47 |
| CHEMBL193867 | — | — | 1 | 7.44 |
| CHEMBL191907 | — | — | 1 | 7.34 |
| CHEMBL195849 | — | — | 1 | 7.31 |
| CHEMBL2112361 | — | — | 1 | 7.21 |
| CHEMBL2112359 | — | — | 1 | 7.17 |
| CHEMBL2112362 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112360 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL86719 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL91588 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL195047 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2112363 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL328292 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL193595 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2112351 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL91021 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL425567 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL193867 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL191907 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL195849 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL2112361 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL2112359 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL2112362 | — | Ki | = | 87.0 | nM | 7.06 |