Assay Detail
Binding
CHEMBL616683
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Ability to displace [3H]8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(R)-11-hydroxy- and (R)-11-hydroxy-10-methylaporphine: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.97 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53510 | — | — | 1 | 9.35 |
| CHEMBL119455 | — | — | 1 | 8.02 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53510 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL119455 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL53 | APOMORPHINE | Ki | = | 296.0 | nM | 6.53 |