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Assay Detail

CHEMBL616691

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Binding
Binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.
Glennon RA, Chaurasia C, Titeler M.
J Med Chem (1990) 33 : 2777 -2784
PubMed 2213830 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.54 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8165 5-METHOXYTRYPTAMINE 1 8.30
CHEMBL31115 1 8.15
CHEMBL439773 2 7.92
CHEMBL96622 1 7.52
CHEMBL96302 1 7.11
CHEMBL30713 1 6.28
CHEMBL328750 1 6.15
CHEMBL92620 1 6.00
CHEMBL92619 1 5.62
CHEMBL428004 1 5.16
CHEMBL96674 1 5.12
CHEMBL96715 1 -
CHEMBL328939 1 -
CHEMBL554032 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8165 5-METHOXYTRYPTAMINE Ki = 5.0 nM 8.30
CHEMBL31115 Ki = 7.0 nM 8.15
CHEMBL439773 Ki = 12.0 nM 7.92
CHEMBL96622 Ki = 30.0 nM 7.52
CHEMBL96302 Ki = 78.0 nM 7.11
CHEMBL30713 Ki = 530.0 nM 6.28
CHEMBL328750 Ki = 715.0 nM 6.15
CHEMBL92620 Ki = 1000.0 nM 6.00
CHEMBL92619 Ki = 2400.0 nM 5.62
CHEMBL428004 Ki = 6850.0 nM 5.16
CHEMBL439773 Ki = 7100.0 nM 5.15
CHEMBL96674 Ki = 7500.0 nM 5.12
CHEMBL96715 Ki > 10000.0 nM -
CHEMBL328939 Ki > 10000.0 nM -
CHEMBL554032 Ki > 10000.0 nM -