Assay Detail
Binding
CHEMBL616692
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Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampus mambranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.16 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.92 |
| CHEMBL151043 | — | — | 1 | 7.47 |
| CHEMBL356250 | — | — | 1 | 7.42 |
| CHEMBL346203 | — | — | 1 | 7.16 |
| CHEMBL152997 | — | — | 1 | 7.15 |
| CHEMBL421787 | — | — | 1 | 7.03 |
| CHEMBL423034 | — | — | 1 | 6.97 |
| CHEMBL357308 | — | — | 1 | 6.93 |
| CHEMBL153685 | — | — | 1 | 6.74 |
| CHEMBL153684 | — | — | 1 | 6.59 |
| CHEMBL150333 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL151043 | — | Ki | = | 33.7 | nM | 7.47 |
| CHEMBL356250 | — | Ki | = | 37.8 | nM | 7.42 |
| CHEMBL346203 | — | Ki | = | 69.7 | nM | 7.16 |
| CHEMBL152997 | — | Ki | = | 70.2 | nM | 7.15 |
| CHEMBL421787 | — | Ki | = | 93.6 | nM | 7.03 |
| CHEMBL423034 | — | Ki | = | 107.8 | nM | 6.97 |
| CHEMBL357308 | — | Ki | = | 117.7 | nM | 6.93 |
| CHEMBL153685 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL153684 | — | Ki | = | 254.3 | nM | 6.59 |
| CHEMBL150333 | — | Ki | = | 445.6 | nM | 6.35 |