Assay Detail

CHEMBL616696

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Binding

Binding affinity against 5-hydroxytryptamine 1A receptor of rat was determined using [3H]8-OH-DPAT in binding assay

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 1A (CHEMBL273) ↗

Open DB target context

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5-hydroxytryptamine receptor 1A (CHEMBL273) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 1A

CHEMBL273

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 1A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL273) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Serotonergic properties of spiroxatrine enantiomers.

Nikam SS, Martin AR, Nelson DL.
J Med Chem (1988) 31 : 1965 -1968
PubMed 2902227 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	8.20	8.72

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL300555	SPIROXATRINE	2.0	2	8.72

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL300555	SPIROXATRINE	Ki	=	1.9	nM	8.72
CHEMBL300555	SPIROXATRINE	Ki	=	21.0	nM	7.68