Assay Detail
Binding
CHEMBL616731
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Binding affinity towards 5-hydroxytryptamine 1D receptor was determined in calf striatum homogenate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.63 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 8.39 |
| CHEMBL110317 | ACETRYPTINE | 2.0 | 1 | 8.01 |
| CHEMBL322349 | — | — | 1 | 7.77 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 7.64 |
| CHEMBL327103 | — | — | 1 | 7.01 |
| CHEMBL109360 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL110317 | ACETRYPTINE | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL322349 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL6640 | TRYPTAMINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL327103 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL109360 | — | Ki | = | 110.0 | nM | 6.96 |