Assay Detail
Binding
CHEMBL616742
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The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gorilla gorilla |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.94 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71838 | — | — | 1 | 9.05 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.70 |
| CHEMBL71635 | — | — | 1 | 8.42 |
| CHEMBL71724 | — | — | 1 | 8.17 |
| CHEMBL69385 | — | — | 1 | 8.07 |
| CHEMBL71907 | — | — | 1 | 6.62 |
| CHEMBL71798 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71838 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL71635 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL71724 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL69385 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL71907 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL71798 | — | Ki | = | 298.0 | nM | 6.53 |