Assay Detail
Binding
CHEMBL616749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.25 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26379 | — | — | 1 | 9.10 |
| CHEMBL26378 | — | — | 1 | 8.92 |
| CHEMBL26906 | — | — | 1 | 8.72 |
| CHEMBL18785 | RU-24969 | — | 1 | 8.70 |
| CHEMBL27592 | — | — | 1 | 8.49 |
| CHEMBL282994 | — | — | 1 | 8.48 |
| CHEMBL283257 | — | — | 1 | 8.46 |
| CHEMBL304008 | — | — | 1 | 7.82 |
| CHEMBL28178 | — | — | 1 | 7.68 |
| CHEMBL274866 | — | — | 1 | 7.57 |
| CHEMBL27403 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26379 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL26378 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL26906 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL18785 | RU-24969 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL27592 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL282994 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL283257 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL304008 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL28178 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL274866 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL27403 | — | IC50 | = | 150.0 | nM | 6.82 |