Assay Detail
Binding
CHEMBL616750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration necessary to achieve half maximal inhibition of [125I]- Iodocyanopindolol binding to 5-hydroxytryptamine 1B receptor at 1 uM
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.69 | 7.29 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274866 | — | — | 1 | 7.29 |
| CHEMBL162449 | — | — | 1 | 6.08 |
| CHEMBL349776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274866 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL162449 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL349776 | — | Inhibition | = | 7.0 | % | - |