Assay Detail
Binding
CHEMBL616761
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.63 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.96 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.51 |
| CHEMBL287987 | — | — | 1 | 5.64 |
| CHEMBL352107 | — | — | 1 | 5.42 |
| CHEMBL43355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL287987 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL352107 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL43355 | — | Ki | > | 4000.0 | nM | - |