Assay Detail
Binding
CHEMBL616771
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Binding affinity was determined against 5-hydroxytryptamine 1B receptor was determined in male Sprague-Dawley rat brain.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.94 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.30 |
| CHEMBL275854 | — | — | 1 | 7.07 |
| CHEMBL266591 | — | — | 1 | 6.28 |
| CHEMBL268800 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL275854 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL266591 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL268800 | — | Ki | = | 800.0 | nM | 6.10 |