Assay Detail
Binding
CHEMBL616773
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Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Central serotonin receptors as targets for drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18785 | RU-24969 | — | 1 | 8.40 |
| CHEMBL18840 | — | — | 1 | 8.30 |
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 7.60 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.60 |
| CHEMBL274866 | — | — | 1 | 7.52 |
| CHEMBL277362 | — | — | 1 | 7.35 |
| CHEMBL452861 | LEVOPROPRANOLOL | 2.0 | 1 | 7.30 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 7.12 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 7.10 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.05 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.50 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 2 | 6.40 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 6.04 |
| CHEMBL275854 | — | — | 1 | 6.00 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | 6.00 |
| CHEMBL18855 | — | — | 1 | 5.98 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 5.72 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 5.33 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 5.32 |
| CHEMBL19264 | — | — | 1 | 5.23 |
| CHEMBL18331 | PIRENPERONE | 2.0 | 1 | 5.18 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 4.99 |
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 4.89 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 4.20 |
| CHEMBL134519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18785 | RU-24969 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL18840 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL39 | SEROTONIN | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19215 | METERGOLINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL274866 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL277362 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL452861 | LEVOPROPRANOLOL | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL500 | PINDOLOL | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL416526 | BUFOTENINE | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL275854 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL18786 | CINANSERIN | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL18855 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL51 | KETANSERIN | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL6437 | MIANSERIN | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL267930 | SPIPERONE | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL19264 | — | Ki | = | 5890.0 | nM | 5.23 |
| CHEMBL18331 | PIRENPERONE | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL6640 | TRYPTAMINE | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL12314 | MESULERGINE | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL134519 | — | Ki | - | nM | - |