Assay Detail
Binding
CHEMBL616775
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Evaluated for binding affinity towards 5-hydroxytryptamine 1B receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.85 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 8.40 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.27 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 6.46 |
| CHEMBL169328 | — | — | 1 | 5.75 |
| CHEMBL141706 | — | — | 1 | 5.37 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL11760 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL39 | SEROTONIN | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL169328 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL141706 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 10000.0 | nM | - |
| CHEMBL11760 | — | Ki | > | 1000.0 | nM | - |