Assay Detail
Binding
CHEMBL616781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1B receptor by displacing [3H]serotonin radioligand in rat cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pyrrole mannich bases as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.11 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153136 | — | — | 1 | 7.35 |
| CHEMBL346168 | — | — | 1 | 7.12 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 7.07 |
| CHEMBL153451 | — | — | 1 | 7.02 |
| CHEMBL347334 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153136 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL346168 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 85.2 | nM | 7.07 |
| CHEMBL153451 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL347334 | — | Ki | = | 100.0 | nM | 7.00 |