Assay Detail
Binding
CHEMBL616782
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for their binding affinity towards 5-hydroxytryptamine 1B receptor from rat striatum using [3H]5-HT as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.32 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.68 |
| CHEMBL59871 | — | — | 1 | 6.38 |
| CHEMBL304016 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL59871 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL304016 | — | Ki | = | 1300.0 | nM | 5.89 |