Assay Detail
Binding
CHEMBL616786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against 5-HT1B receptor in rat frontal cortex using [3H]-5-HT in presence of 0.1 uM [3H]-8-OH-DPAT as a radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.62 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275742 | DEXPROPRANOLOL | 2.0 | 1 | 6.31 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 6.00 |
| CHEMBL273490 | — | — | 1 | 5.49 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.42 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275742 | DEXPROPRANOLOL | IC50 | = | 489.78 | nM | 6.31 |
| CHEMBL267930 | SPIPERONE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL273490 | — | IC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 12589.25 | nM | 4.90 |