Assay Detail
Binding
CHEMBL616790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT from 5-HT1B receptor of rat frontal cortex homogenate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.36 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.46 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 8.19 |
| CHEMBL1416204 | — | — | 1 | 7.34 |
| CHEMBL1788239 | — | — | 1 | 6.92 |
| CHEMBL1788281 | — | — | 1 | 6.42 |
| CHEMBL2093088 | — | — | 1 | 6.38 |
| CHEMBL1744072 | — | — | 1 | 6.11 |
| CHEMBL1788285 | — | — | 1 | 5.86 |
| CHEMBL2093087 | — | — | 1 | 5.82 |
| CHEMBL1788284 | — | — | 1 | 5.81 |
| CHEMBL1744073 | — | — | 1 | 5.67 |
| CHEMBL1788280 | — | — | 1 | 5.57 |
| CHEMBL1744074 | — | — | 1 | 5.39 |
| CHEMBL1788282 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL1416204 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL1788239 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL1788281 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL2093088 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL1744072 | — | Ki | = | 776.25 | nM | 6.11 |
| CHEMBL1788285 | — | Ki | = | 1380.38 | nM | 5.86 |
| CHEMBL2093087 | — | Ki | = | 1513.56 | nM | 5.82 |
| CHEMBL1788284 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL1744073 | — | Ki | = | 2137.96 | nM | 5.67 |
| CHEMBL1788280 | — | Ki | = | 2691.53 | nM | 5.57 |
| CHEMBL1744074 | — | Ki | = | 4073.8 | nM | 5.39 |
| CHEMBL1788282 | — | Ki | = | 7244.36 | nM | 5.14 |