Assay Detail
Binding
CHEMBL616791
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Binding affinity at 5-hydroxytryptamine 1B receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.25 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282614 | ELTOPRAZINE | 2.0 | 1 | 7.27 |
| CHEMBL131011 | — | — | 1 | 6.70 |
| CHEMBL130734 | — | — | 1 | 6.69 |
| CHEMBL131198 | — | — | 1 | 6.67 |
| CHEMBL131200 | — | — | 1 | 6.64 |
| CHEMBL130870 | — | — | 1 | 6.60 |
| CHEMBL129947 | — | — | 1 | 6.50 |
| CHEMBL131018 | — | — | 1 | 6.50 |
| CHEMBL128546 | — | — | 1 | 6.42 |
| CHEMBL341391 | — | — | 1 | 6.38 |
| CHEMBL335010 | — | — | 1 | 6.31 |
| CHEMBL334381 | — | — | 1 | 6.26 |
| CHEMBL131184 | — | — | 1 | 6.25 |
| CHEMBL130276 | — | — | 1 | 6.22 |
| CHEMBL337078 | — | — | 1 | 6.21 |
| CHEMBL131900 | — | — | 1 | 6.20 |
| CHEMBL130976 | — | — | 1 | 6.19 |
| CHEMBL133188 | — | — | 1 | 6.17 |
| CHEMBL129993 | — | — | 1 | 6.16 |
| CHEMBL341390 | — | — | 1 | 6.15 |
| CHEMBL132514 | — | — | 1 | 6.15 |
| CHEMBL337279 | — | — | 1 | 6.11 |
| CHEMBL335297 | — | — | 1 | 6.10 |
| CHEMBL131324 | — | — | 1 | 6.04 |
| CHEMBL337036 | — | — | 1 | 6.03 |
| CHEMBL8618 | NAN-190 | — | 1 | 5.97 |
| CHEMBL132657 | — | — | 1 | 5.96 |
| CHEMBL335752 | — | — | 1 | 5.85 |
| CHEMBL127216 | — | — | 1 | 5.85 |
| CHEMBL132878 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282614 | ELTOPRAZINE | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL131011 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL130734 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL131198 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL131200 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL130870 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL129947 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL131018 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL128546 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL341391 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL335010 | — | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL334381 | — | Ki | = | 549.54 | nM | 6.26 |
| CHEMBL131184 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL130276 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL337078 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL131900 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL130976 | — | Ki | = | 645.65 | nM | 6.19 |
| CHEMBL133188 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL129993 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL341390 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL132514 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL337279 | — | Ki | = | 776.25 | nM | 6.11 |
| CHEMBL335297 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL131324 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL337036 | — | Ki | = | 933.25 | nM | 6.03 |
| CHEMBL8618 | NAN-190 | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL132657 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL335752 | — | Ki | = | 1412.54 | nM | 5.85 |
| CHEMBL127216 | — | Ki | = | 1412.54 | nM | 5.85 |
| CHEMBL132878 | — | Ki | = | 1513.56 | nM | 5.82 |
| CHEMBL49247 | — | Ki | = | 1778.28 | nM | 5.75 |
| CHEMBL130103 | — | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL13647 | BMY-7378 | Ki | > | 10000.0 | nM | - |
| CHEMBL38288 | — | Ki | > | 10000.0 | nM | - |