Assay Detail
Binding
CHEMBL616793
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In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindolol
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.30 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15928 | GR-127935 | — | 1 | 8.50 |
| CHEMBL311150 | — | — | 1 | 8.20 |
| CHEMBL306384 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15928 | GR-127935 | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL311150 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL306384 | — | Ki | = | 6.31 | nM | 8.20 |