Assay Detail
Binding
CHEMBL616795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for the binding affinity against 5-hydroxytryptamine 1B receptor using [3H]5-HT as radioligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.58 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.60 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.70 |
| CHEMBL342690 | — | — | 1 | 6.60 |
| CHEMBL136978 | — | — | 1 | 6.40 |
| CHEMBL136108 | — | — | 1 | 5.80 |
| CHEMBL337101 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL342690 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL136978 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL136108 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL337101 | — | Ki | = | 3981.07 | nM | 5.40 |