Assay Detail
Binding
CHEMBL616828
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Binding affinity towards 5-hydroxytryptamine 1C receptor using [125 I]-SCH23982 as radioligand in competitive binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.72 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314459 | — | — | 1 | 6.13 |
| CHEMBL419680 | — | — | 1 | 5.90 |
| CHEMBL83080 | — | — | 1 | 5.80 |
| CHEMBL315468 | — | — | 1 | 5.03 |
| CHEMBL86931 | — | — | 1 | - |
| CHEMBL82899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314459 | — | Ki | = | 736.0 | nM | 6.13 |
| CHEMBL419680 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL83080 | — | Ki | = | 1590.0 | nM | 5.80 |
| CHEMBL315468 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL86931 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL82899 | — | Ki | > | 10000.0 | nM | - |