Assay Detail
Binding
CHEMBL616834
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Binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine as radioligand
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.54 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8569 | — | — | 1 | 7.85 |
| CHEMBL8214 | — | — | 1 | 7.58 |
| CHEMBL6616 | — | — | 1 | 7.52 |
| CHEMBL292821 | — | — | 1 | 7.44 |
| CHEMBL69700 | — | — | 1 | 7.30 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.16 |
| CHEMBL468880 | — | — | 1 | 7.08 |
| CHEMBL317634 | — | — | 1 | 7.05 |
| CHEMBL351858 | — | — | 1 | 7.01 |
| CHEMBL60146 | — | — | 1 | 7.00 |
| CHEMBL8224 | — | — | 1 | 7.00 |
| CHEMBL162122 | — | — | 1 | 6.96 |
| CHEMBL161905 | — | — | 1 | 6.89 |
| CHEMBL8600 | DOM | — | 1 | 6.71 |
| CHEMBL163985 | — | — | 1 | 6.66 |
| CHEMBL166040 | — | — | 1 | 6.21 |
| CHEMBL8642 | — | — | 1 | 5.92 |
| CHEMBL61355 | — | — | 1 | 5.83 |
| CHEMBL166041 | — | — | 1 | 5.83 |
| CHEMBL162209 | — | — | 1 | 5.81 |
| CHEMBL163814 | — | — | 1 | 5.71 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 5.68 |
| CHEMBL8225 | — | — | 1 | 5.64 |
| CHEMBL8389 | — | — | 1 | 5.57 |
| CHEMBL282734 | — | — | 1 | 5.35 |
| CHEMBL30336 | — | — | 1 | 5.24 |
| CHEMBL273251 | — | — | 1 | - |
| CHEMBL18762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8569 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL8214 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL6616 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL292821 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL69700 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL468880 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL317634 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL351858 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL60146 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL8224 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL162122 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL161905 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL8600 | DOM | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL163985 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL166040 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL8642 | — | Ki | = | 1217.0 | nM | 5.92 |
| CHEMBL61355 | — | Ki | = | 1485.0 | nM | 5.83 |
| CHEMBL166041 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL162209 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL163814 | — | Ki | = | 1935.0 | nM | 5.71 |
| CHEMBL6731 | TENAMFETAMINE | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL8225 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL8389 | — | Ki | = | 2666.0 | nM | 5.57 |
| CHEMBL282734 | — | Ki | = | 4475.0 | nM | 5.35 |
| CHEMBL30336 | — | Ki | = | 5710.0 | nM | 5.24 |
| CHEMBL273251 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL18762 | — | Ki | > | 10000.0 | nM | - |