Assay Detail
Binding
CHEMBL616841
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In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.52 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28437 | — | — | 1 | 6.90 |
| CHEMBL554220 | — | — | 1 | 6.47 |
| CHEMBL26998 | — | — | 1 | 6.20 |
| CHEMBL2021525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28437 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL554220 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL26998 | — | Ki | = | 638.0 | nM | 6.20 |
| CHEMBL2021525 | — | Ki | > | 1500.0 | nM | - |