Assay Detail
Binding
CHEMBL616844
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Inhibitory activity against 5-hydroxytryptamine 1E receptor subtype
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bivalent indoles exhibiting serotonergic binding affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.71 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22744 | — | — | 1 | 7.00 |
| CHEMBL22961 | — | — | 1 | 6.41 |
| CHEMBL22553 | — | — | 1 | - |
| CHEMBL281575 | — | — | 1 | - |
| CHEMBL21862 | — | — | 1 | - |
| CHEMBL278610 | — | — | 1 | - |
| CHEMBL17828 | — | — | 1 | - |
| CHEMBL277452 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22744 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL22961 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL22553 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL281575 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL21862 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL278610 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL17828 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL277452 | — | IC50 | > | 1000.0 | nM | - |