Assay Detail
Binding
CHEMBL616859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells using [3H]5-HT as radioligand.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.16 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788231 | — | — | 1 | 6.30 |
| CHEMBL116448 | — | — | 1 | 6.30 |
| CHEMBL94984 | — | — | 1 | 6.20 |
| CHEMBL333784 | — | — | 1 | 6.20 |
| CHEMBL282199 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788231 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL116448 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL94984 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL333784 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL282199 | — | Ki | = | 1584.89 | nM | 5.80 |