Assay Detail
Binding
CHEMBL616875
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Binding affinity towards 5-hydroxytryptamine 2A receptor (human cloned receptor) in HEK 293 cells using [3H]ketanserin as radioligand.
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.80 | 5.80 |
| Log Ki | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94984 | — | — | 1 | 5.80 |
| CHEMBL332701 | — | — | 1 | - |
| CHEMBL94261 | — | — | 1 | - |
| CHEMBL282199 | — | — | 1 | - |
| CHEMBL114012 | — | — | 1 | - |
| CHEMBL152595 | — | — | 1 | - |
| CHEMBL12624 | SB-258741 | — | 1 | - |
| CHEMBL1788231 | — | — | 1 | - |
| CHEMBL333784 | — | — | 1 | - |
| CHEMBL116448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94984 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL332701 | — | Log Ki | - | — | - | |
| CHEMBL94261 | — | Log Ki | - | — | - | |
| CHEMBL282199 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL114012 | — | Ki | < | 3162.28 | nM | - |
| CHEMBL152595 | — | Log Ki | - | — | - | |
| CHEMBL12624 | SB-258741 | Ki | < | 5011.87 | nM | - |
| CHEMBL1788231 | — | Ki | < | 2511.89 | nM | - |
| CHEMBL333784 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL116448 | — | Ki | < | 5011.87 | nM | - |