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Compound Detail

CHEMBL332701

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COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1

Basic Information

ChEMBL ID CHEMBL332701
Phase Preclinical
Structure Type MOL
InChI Key SIGPAXROBLPQJS-QGZVFWFLSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names

Molecular Properties

366.5
MW (Da)
2.97
ALogP
4
HBA
0
HBD
49.9
PSA (Ų)
0.78
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H30N2O3S
MW 366.53
Aromatic Rings 1
Heavy Atoms 25
NP-Likeness -1.64

Activity Summary

Ki 4 meas. best 8.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma intracellular receptor 2
CHEMBL4105907
Ki 8.8 8.8 1.6 1
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 8.04 8.04 9.2 1
5-hydroxytryptamine receptor 7
CHEMBL3155
Ki 8.0 7.875 10.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 2C 1
35939391 10.1021/acs.jmedchem.2c00633 Sigma intracellular receptor 2 1
35939391 10.1021/acs.jmedchem.2c00633 Sigma non-opioid intracellular receptor 1 1
35939391 10.1021/acs.jmedchem.2c00633 5-hydroxytryptamine receptor 7 1
10669560 10.1021/jm991151j D(3) dopamine receptor 1
10669560 10.1021/jm991151j D(2) dopamine receptor 1
10669560 10.1021/jm991151j Alpha-1B adrenergic receptor 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 5A 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 4 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 6 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 2B 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 2A 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 1F 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 1E 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 1D 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 1B 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 1A 1
10669560 10.1021/jm991151j 5-hydroxytryptamine receptor 7 1

Data from ChEMBL 36 via Core Engine