Assay Detail
Binding
CHEMBL616900
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Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.00 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420965 | — | — | 1 | 9.22 |
| CHEMBL85668 | — | — | 1 | 9.15 |
| CHEMBL82204 | — | — | 1 | 9.10 |
| CHEMBL84070 | — | — | 1 | 9.05 |
| CHEMBL83426 | — | — | 1 | 9.05 |
| CHEMBL84712 | — | — | 1 | 8.92 |
| CHEMBL310061 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420965 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL85668 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL82204 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL84070 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL83426 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL84712 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL310061 | — | IC50 | = | 3.3 | nM | 8.48 |