Assay Detail
Binding
CHEMBL616901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines: selective h5-HT1D agonists for the treatment of migraine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.74 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112507 | — | — | 1 | 10.00 |
| CHEMBL326125 | — | — | 1 | 9.35 |
| CHEMBL116161 | — | — | 1 | 9.19 |
| CHEMBL331819 | — | — | 1 | 9.19 |
| CHEMBL111899 | — | — | 1 | 8.92 |
| CHEMBL114877 | — | — | 1 | 8.92 |
| CHEMBL114303 | — | — | 1 | 8.89 |
| CHEMBL115989 | — | — | 1 | 8.87 |
| CHEMBL115352 | — | — | 1 | 8.74 |
| CHEMBL112558 | — | — | 1 | 8.49 |
| CHEMBL324751 | — | — | 1 | 8.40 |
| CHEMBL331143 | — | — | 1 | 8.35 |
| CHEMBL113831 | — | — | 1 | 8.14 |
| CHEMBL326723 | — | — | 1 | 7.96 |
| CHEMBL115496 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112507 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL326125 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL116161 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL331819 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL111899 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL114877 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL114303 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL115989 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL115352 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL112558 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL324751 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL331143 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL113831 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL326723 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL115496 | — | IC50 | = | 21.0 | nM | 7.68 |