Assay Detail
Binding
CHEMBL616902
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Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.31 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160070 | — | — | 1 | 9.52 |
| CHEMBL159483 | — | — | 1 | 9.46 |
| CHEMBL420965 | — | — | 1 | 9.30 |
| CHEMBL161780 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160070 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL159483 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL420965 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL161780 | — | IC50 | = | 1.1 | nM | 8.96 |