Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL616907

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
ChEMBL ↗
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1D (CHEMBL1983) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
Russell MG, Matassa VG, Pengilley RR, van Niel MB, Sohal B, Watt AP, Hitzel L, Beer MS, Stanton JA, Broughton HB, Castro JL.
J Med Chem (1999) 42 : 4981 -5001
PubMed 10585208 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 8.34 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331970 — — 1 9.40
CHEMBL148233 — — 1 9.30
CHEMBL147660 — — 1 9.22
CHEMBL146483 — — 1 9.22
CHEMBL434125 — — 1 9.15
CHEMBL313714 — — 1 9.05
CHEMBL333341 — — 1 9.05
CHEMBL143947 — — 1 9.05
CHEMBL356808 — — 1 8.96
CHEMBL146991 — — 1 8.92
CHEMBL343217 — — 1 8.85
CHEMBL343648 — — 1 8.85
CHEMBL147818 — — 1 8.82
CHEMBL146024 — — 1 8.82
CHEMBL146338 — — 1 8.82
CHEMBL357634 — — 1 8.82
CHEMBL143893 — — 1 8.80
CHEMBL145982 — — 1 8.80
CHEMBL358072 — — 1 8.77
CHEMBL147838 — — 1 8.72
CHEMBL304857 — — 1 8.68
CHEMBL357007 — — 1 8.59
CHEMBL146335 — — 1 8.52
CHEMBL116092 — — 1 8.51
CHEMBL146265 — — 1 8.47
CHEMBL147961 — — 1 8.39
CHEMBL147940 — — 1 8.38
CHEMBL147907 — — 1 8.38
CHEMBL423212 — — 1 8.37
CHEMBL146391 — — 1 8.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331970 — IC50 = 0.4 nM 9.40
CHEMBL148233 — IC50 = 0.5 nM 9.30
CHEMBL146483 — IC50 = 0.6 nM 9.22
CHEMBL147660 — IC50 = 0.6 nM 9.22
CHEMBL434125 — IC50 = 0.7 nM 9.15
CHEMBL313714 — IC50 = 0.9 nM 9.05
CHEMBL333341 — IC50 = 0.9 nM 9.05
CHEMBL143947 — IC50 = 0.9 nM 9.05
CHEMBL356808 — IC50 = 1.1 nM 8.96
CHEMBL146991 — IC50 = 1.2 nM 8.92
CHEMBL343217 — IC50 = 1.4 nM 8.85
CHEMBL343648 — IC50 = 1.4 nM 8.85
CHEMBL146024 — IC50 = 1.5 nM 8.82
CHEMBL147818 — IC50 = 1.5 nM 8.82
CHEMBL146338 — IC50 = 1.5 nM 8.82
CHEMBL357634 — IC50 = 1.5 nM 8.82
CHEMBL143893 — IC50 = 1.6 nM 8.80
CHEMBL145982 — IC50 = 1.6 nM 8.80
CHEMBL358072 — IC50 = 1.7 nM 8.77
CHEMBL147838 — IC50 = 1.9 nM 8.72
CHEMBL304857 — IC50 = 2.1 nM 8.68
CHEMBL357007 — IC50 = 2.6 nM 8.59
CHEMBL146335 — IC50 = 3.0 nM 8.52
CHEMBL116092 — IC50 = 3.1 nM 8.51
CHEMBL146265 — IC50 = 3.4 nM 8.47
CHEMBL147961 — IC50 = 4.1 nM 8.39
CHEMBL147907 — IC50 = 4.2 nM 8.38
CHEMBL147940 — IC50 = 4.2 nM 8.38
CHEMBL423212 — IC50 = 4.3 nM 8.37
CHEMBL146391 — IC50 = 4.4 nM 8.36
CHEMBL357408 — IC50 = 4.5 nM 8.35
CHEMBL117046 — IC50 = 4.6 nM 8.34
CHEMBL344537 — IC50 = 5.0 nM 8.30
CHEMBL147546 — IC50 = 5.7 nM 8.24
CHEMBL147148 — IC50 = 5.9 nM 8.23
CHEMBL147979 — IC50 = 5.9 nM 8.23
CHEMBL145849 — IC50 = 6.0 nM 8.22
CHEMBL143952 — IC50 = 6.2 nM 8.21
CHEMBL146129 — IC50 = 6.3 nM 8.20
CHEMBL2112862 — IC50 = 6.6 nM 8.18
CHEMBL356315 — IC50 = 7.6 nM 8.12
CHEMBL343667 — IC50 = 8.1 nM 8.09
CHEMBL148085 — IC50 = 8.1 nM 8.09
CHEMBL148095 — IC50 = 8.9 nM 8.05
CHEMBL434315 — IC50 = 9.3 nM 8.03
CHEMBL146023 — IC50 = 12.0 nM 7.92
CHEMBL143951 — IC50 = 12.0 nM 7.92
CHEMBL145997 — IC50 = 14.0 nM 7.85
CHEMBL347570 — IC50 = 17.0 nM 7.77
CHEMBL147555 — IC50 = 18.0 nM 7.75