Assay Detail
Binding
CHEMBL616909
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Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.72 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296161 | — | — | 1 | 9.52 |
| CHEMBL420965 | — | — | 1 | 9.22 |
| CHEMBL163462 | — | — | 1 | 8.64 |
| CHEMBL116092 | — | — | 1 | 8.51 |
| CHEMBL163376 | — | — | 1 | 8.28 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296161 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL420965 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL163462 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL116092 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL163376 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL128 | SUMATRIPTAN | IC50 | = | 6.7 | nM | 8.17 |