Assay Detail
Binding
CHEMBL616919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.40 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81191 | — | — | 1 | 8.27 |
| CHEMBL79674 | — | — | 1 | 8.08 |
| CHEMBL79693 | — | — | 1 | 7.85 |
| CHEMBL1169435 | — | — | 1 | 7.82 |
| CHEMBL81703 | — | — | 1 | 7.70 |
| CHEMBL441259 | — | — | 1 | 7.62 |
| CHEMBL1159649 | — | — | 1 | 7.60 |
| CHEMBL83112 | — | — | 1 | 7.58 |
| CHEMBL83732 | — | — | 1 | 7.58 |
| CHEMBL2112307 | — | — | 1 | 7.57 |
| CHEMBL82488 | — | — | 1 | 7.55 |
| CHEMBL311787 | — | — | 1 | 7.55 |
| CHEMBL84171 | — | — | 1 | 7.51 |
| CHEMBL444843 | — | — | 1 | 7.40 |
| CHEMBL79725 | — | — | 1 | 7.40 |
| CHEMBL442974 | — | — | 1 | 7.29 |
| CHEMBL83617 | — | — | 1 | 7.25 |
| CHEMBL82523 | — | — | 1 | 7.24 |
| CHEMBL79853 | — | — | 1 | 7.20 |
| CHEMBL311323 | — | — | 1 | 7.19 |
| CHEMBL310082 | — | — | 1 | 7.15 |
| CHEMBL310744 | — | — | 1 | 7.13 |
| CHEMBL313452 | — | — | 1 | 6.91 |
| CHEMBL311694 | — | — | 1 | 6.89 |
| CHEMBL79561 | — | — | 1 | 6.89 |
| CHEMBL309872 | — | — | 1 | 6.84 |
| CHEMBL84305 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81191 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL79674 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL79693 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1169435 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL81703 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL441259 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1159649 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL83112 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL83732 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2112307 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL82488 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL311787 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL84171 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL444843 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL79725 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL442974 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL83617 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL82523 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL79853 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL311323 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL310082 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL310744 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL313452 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL311694 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL79561 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL309872 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL84305 | — | Ki | = | 165.0 | nM | 6.78 |