Assay Detail
Binding
CHEMBL616922
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Binding affinity was evaluated at the cloned human 5-hydroxytryptamine 1D receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.91 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.47 |
| CHEMBL159278 | — | — | 1 | 8.21 |
| CHEMBL162724 | — | — | 1 | 8.21 |
| CHEMBL162049 | — | — | 1 | 8.13 |
| CHEMBL428991 | — | — | 1 | 8.11 |
| CHEMBL115415 | — | — | 1 | 8.10 |
| CHEMBL163151 | — | — | 1 | 8.07 |
| CHEMBL162012 | — | — | 1 | 8.07 |
| CHEMBL423789 | — | — | 1 | 8.06 |
| CHEMBL349903 | — | — | 1 | 8.03 |
| CHEMBL352181 | — | — | 1 | 8.02 |
| CHEMBL348756 | — | — | 1 | 7.96 |
| CHEMBL349675 | — | — | 1 | 7.96 |
| CHEMBL351036 | — | — | 1 | 7.92 |
| CHEMBL349174 | — | — | 1 | 7.92 |
| CHEMBL161894 | — | — | 1 | 7.80 |
| CHEMBL163639 | — | — | 1 | 7.68 |
| CHEMBL162011 | — | — | 1 | 7.57 |
| CHEMBL440008 | — | — | 1 | 7.54 |
| CHEMBL163516 | — | — | 1 | 7.54 |
| CHEMBL162771 | — | — | 1 | 7.54 |
| CHEMBL422192 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128 | SUMATRIPTAN | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL159278 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL162724 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL162049 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL428991 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL115415 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL163151 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL162012 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL423789 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL349903 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL352181 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL348756 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL349675 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL351036 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL349174 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL161894 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL163639 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL162011 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL440008 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL163516 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL162771 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL422192 | — | Ki | = | 74.0 | nM | 7.13 |