Assay Detail
Binding
CHEMBL616932
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In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.75 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1185 | ZOLMITRIPTAN | 4.0 | 1 | 9.12 |
| CHEMBL158941 | — | — | 1 | 9.05 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1185 | ZOLMITRIPTAN | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL158941 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 8.6 | nM | 8.07 |