Assay Detail
Binding
CHEMBL616934
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Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.05 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129813 | — | — | 1 | 9.35 |
| CHEMBL2112660 | — | — | 1 | 9.29 |
| CHEMBL2112662 | — | — | 1 | 9.26 |
| CHEMBL338015 | — | — | 1 | 9.21 |
| CHEMBL340786 | — | — | 1 | 9.16 |
| CHEMBL129661 | — | — | 1 | 9.15 |
| CHEMBL339308 | — | — | 1 | 9.13 |
| CHEMBL2112661 | — | — | 1 | 9.06 |
| CHEMBL128699 | — | — | 1 | 8.72 |
| CHEMBL277120 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129813 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL2112660 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL2112662 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL338015 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL340786 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL129661 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL339308 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL2112661 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL128699 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL277120 | — | Ki | = | 6.2 | nM | 8.21 |