Assay Detail
Binding
CHEMBL616951
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Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.08 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505765 | — | — | 1 | 8.50 |
| CHEMBL541621 | — | — | 1 | 8.21 |
| CHEMBL2368632 | — | — | 1 | 8.10 |
| CHEMBL545095 | — | — | 1 | 6.82 |
| CHEMBL542510 | — | — | 1 | 6.41 |
| CHEMBL542753 | — | — | 1 | 5.86 |
| CHEMBL544668 | — | — | 1 | 5.69 |
| CHEMBL555263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505765 | — | Ki | = | 3.18 | nM | 8.50 |
| CHEMBL541621 | — | Ki | = | 6.11 | nM | 8.21 |
| CHEMBL2368632 | — | Ki | = | 8.04 | nM | 8.10 |
| CHEMBL545095 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL542510 | — | Ki | = | 394.0 | nM | 6.41 |
| CHEMBL542753 | — | Ki | = | 1389.0 | nM | 5.86 |
| CHEMBL544668 | — | Ki | = | 2021.0 | nM | 5.69 |
| CHEMBL555263 | — | Ki | > | 10000.0 | nM | - |