Assay Detail
Binding
CHEMBL616953
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Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]WB-4101 displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.58 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9669 | — | — | 1 | 8.12 |
| CHEMBL273923 | — | — | 1 | 8.04 |
| CHEMBL9666 | — | — | 1 | 8.02 |
| CHEMBL9452 | — | — | 1 | 7.96 |
| CHEMBL276156 | — | — | 1 | 7.90 |
| CHEMBL9921 | — | — | 1 | 7.72 |
| CHEMBL9870 | — | — | 1 | 7.71 |
| CHEMBL9841 | — | — | 1 | 7.71 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 7.64 |
| CHEMBL9467 | — | — | 1 | 7.64 |
| CHEMBL275943 | — | — | 1 | 7.59 |
| CHEMBL9746 | — | — | 1 | 7.56 |
| CHEMBL266250 | — | — | 1 | 7.45 |
| CHEMBL9429 | — | — | 1 | 7.37 |
| CHEMBL269784 | — | — | 1 | 6.94 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 6.83 |
| CHEMBL269521 | MK-212 | — | 1 | 6.70 |
| CHEMBL267153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9669 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL273923 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL9666 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL9452 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL276156 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL9921 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL9870 | — | Ki | = | 19.4 | nM | 7.71 |
| CHEMBL9841 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL9467 | — | Ki | = | 22.7 | nM | 7.64 |
| CHEMBL275943 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL9746 | — | Ki | = | 27.4 | nM | 7.56 |
| CHEMBL266250 | — | Ki | = | 35.3 | nM | 7.45 |
| CHEMBL9429 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL269784 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL269521 | MK-212 | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL267153 | — | Ki | ~ | 322.0 | nM | - |