Assay Detail
Binding
CHEMBL616983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-hydroxytryptamine 2 receptor by 3H ligand binding experiments.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.45 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 8.01 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 4.88 |
| CHEMBL1733174 | MOSAPRIDE CITRATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1733174 | MOSAPRIDE CITRATE | IC50 | > | 100000.0 | nM | - |