Assay Detail
Binding
CHEMBL617020
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Binding affinity at 5-hydroxytryptamine 2 receptor determined using [125I]- DOI as radioligand in rat frontal cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (CHEMBL2111383) ↗| Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
Publication
[125I]-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane: an iodinated radioligand that specifically labels the agonist high-affinity state of 5-HT2 serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.39 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69700 | — | — | 1 | 8.72 |
| CHEMBL6616 | — | — | 1 | 8.55 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | 8.30 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69700 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL6616 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL18786 | CINANSERIN | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL39 | SEROTONIN | Ki | = | 10.6 | nM | 7.97 |