Assay Detail
Binding
CHEMBL617039
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Binding affinity towards 5-hydroxytryptamine 2 receptor expressed in CHO cell membranes using [3H]ketanserin (60 Ci/mmol, 1 nM)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.05 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103983 | — | — | 1 | 7.56 |
| CHEMBL418802 | — | — | 1 | 7.50 |
| CHEMBL318374 | — | — | 1 | 7.41 |
| CHEMBL102175 | — | — | 1 | 7.03 |
| CHEMBL318166 | — | — | 1 | 6.84 |
| CHEMBL319023 | — | — | 1 | 6.77 |
| CHEMBL101483 | — | — | 1 | 6.77 |
| CHEMBL101535 | — | — | 1 | 6.55 |
| CHEMBL320880 | — | — | 1 | - |
| CHEMBL323088 | — | — | 1 | - |
| CHEMBL106283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103983 | — | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL418802 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL318374 | — | Ki | = | 38.7 | nM | 7.41 |
| CHEMBL102175 | — | Ki | = | 92.6 | nM | 7.03 |
| CHEMBL318166 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL319023 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL101483 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL101535 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL320880 | — | Ki | > | 1722.0 | nM | - |
| CHEMBL323088 | — | Ki | > | 1722.0 | nM | - |
| CHEMBL106283 | — | Ki | > | 1722.0 | nM | - |