Assay Detail
Functional
CHEMBL617040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 9.04 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL161176 | — | — | 1 | 9.70 |
| CHEMBL163462 | — | — | 1 | 9.70 |
| CHEMBL65367 | — | — | 1 | 9.70 |
| CHEMBL162722 | — | — | 1 | 9.52 |
| CHEMBL163386 | — | — | 1 | 9.52 |
| CHEMBL163573 | — | — | 1 | 9.52 |
| CHEMBL164111 | — | — | 1 | 9.52 |
| CHEMBL161723 | — | — | 1 | 9.52 |
| CHEMBL422366 | — | — | 1 | 9.52 |
| CHEMBL162805 | — | — | 1 | 9.30 |
| CHEMBL159396 | — | — | 1 | 9.22 |
| CHEMBL119668 | — | — | 1 | 9.15 |
| CHEMBL164035 | — | — | 1 | 9.10 |
| CHEMBL162858 | — | — | 1 | 9.00 |
| CHEMBL292779 | — | — | 1 | 9.00 |
| CHEMBL347665 | — | — | 1 | 8.96 |
| CHEMBL161696 | — | — | 1 | 8.92 |
| CHEMBL116031 | — | — | 1 | 8.85 |
| CHEMBL115750 | — | — | 1 | 8.82 |
| CHEMBL348962 | — | — | 1 | 8.77 |
| CHEMBL117633 | — | — | 1 | 8.77 |
| CHEMBL119785 | — | — | 1 | 8.74 |
| CHEMBL164413 | — | — | 1 | 8.70 |
| CHEMBL352159 | — | — | 1 | 8.64 |
| CHEMBL352123 | — | — | 1 | 8.40 |
| CHEMBL163127 | — | — | 1 | 8.21 |
| CHEMBL162899 | — | — | 1 | 8.12 |
| CHEMBL351311 | — | — | 1 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL161176 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL163462 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL65367 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL162722 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL163386 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL163573 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL164111 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL161723 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL422366 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL162805 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL159396 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL119668 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL164035 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL162858 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL292779 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL347665 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL161696 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL116031 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL115750 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL348962 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL117633 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL119785 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL164413 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL352159 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL352123 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL163127 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL162899 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL351311 | — | EC50 | = | 7.8 | nM | 8.11 |